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Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of NorthernChina?

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 113-117 doi: 10.1007/s11684-014-0310-x

摘要：

Papillary thyroid carcinoma (PTC) is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 (located at the 14q13.3 locus), which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained (C vs. T, P=0.027, OR=1.264, 95% CI=1.026-1.557; and C/C-C/T vs. T/T, P=0.034, OR=1.474, 95% CI=1.028-2.112). Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 (adjusted P=0.062) between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction (P=0.029; OR=2.578, 95% CI=1.104-6.023) between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.

关键词： NKX2-1     papillary thyroid carcinoma     the Han population of Northern China     association    

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南海北部深水区油气勘探进展与未来展望

米立军 ,周守为 ,谢玉洪 ,张功成 ,杨海长

《中国工程科学》 2022年 第24卷 第3期   页码 58-65 doi: 10.15302/J-SSCAE-2022.03.007

摘要：

加大油气勘探开发力度，减少石油和天然气对外依存度，保障国家能源安全是关系国家经济社会发展的全局性、战略性问题。“十一五”以来，中国海洋石油集团有限公司在南海北部深水领域持续加强基础研究，加快技术创新和加大勘探投入，相继获得一批重大油气勘探发现。本文阐述了五项重大勘探地质理论认识和两项勘探技术创新成果，探讨了深水油气勘探将要面临的挑战和应对策略，展望了南海北部深水区中深层、潜山及岩性圈闭三大领域的勘探前景。研究指出，南海北部陆缘深水区的拆离作用控制了珠江口盆地和琼东南盆地大型凹陷的形成，发育了湖相、海陆过渡相和海相三套规模烃源岩；高‒ 变地温控制凹陷烃源岩快速生烃，建立了琼东南盆地深水区大型轴向峡谷水道油气成藏模式、白云凹陷深水区深水扇天然气晚期成藏模式和深水区“断‒ 脊”联控油气差异聚集成藏模式。同时自主创新研发了立体震源激发和“犁形”缆接收的宽频采集处理技术。在多项地质理论认识和创新技术的指导下，发现以“深海一号”（陵水17-2）等为代表的一批大中型气田，对于保障粤港澳大湾区能源供应、促进海南自贸区（港）能源绿色发展、推动我国油气增储上产具有重要意义。

关键词： 南海北部；深水区；油气勘探；深水天然气    

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Improving simulations of sulfate aerosols during winter haze over Northern China: the impacts of heterogeneous

Meng Gao,Gregory R. Carmichael,Yuesi Wang,Dongsheng Ji,Zirui Liu,Zifa Wang

《环境科学与工程前沿（英文）》 2016年 第10卷 第5期 doi: 10.1007/s11783-016-0878-2

摘要： Incorporating the missing heterogeneous oxidation of S(IV) by NO into the WRF-Chem model. Sulfate production is not sensitive to increase in SO emission. The newly added reaction reproduces sulfate concentrations well during winter haze. We implemented the online coupled WRF-Chem model to reproduce the 2013 January haze event in North China, and evaluated simulated meteorological and chemical fields using multiple observations. The comparisons suggest that temperature and relative humidity (RH) were simulated well (mean biases are -0.2K and 2.7%, respectively), but wind speeds were overestimated (mean bias is 0.5 m?s ). At the Beijing station, sulfur dioxide (SO ) concentrations were overpredicted and sulfate concentrations were largely underpredicted, which may result from uncertainties in SO emissions and missing heterogeneous oxidation in current model. We conducted three parallel experiments to examine the impacts of doubling SO emissions and incorporating heterogeneous oxidation of dissolved SO by nitrogen dioxide (NO ) on sulfate formation during winter haze. The results suggest that doubling SO emissions do not significantly affect sulfate concentrations, but adding heterogeneous oxidation of dissolved SO by NO substantially improve simulations of sulfate and other inorganic aerosols. Although the enhanced SO to sulfate conversion in the HetS (heterogeneous oxidation by NO ) case reduces SO concentrations, it is still largely overestimated by the model, indicating the overestimations of SO concentrations in the North China Plain (NCP) are mostly due to errors in SO emission inventory.

关键词： Sulfate aerosols     Winter haze     WRF-Chem     Northern China    

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Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

《医学前沿（英文）》 2022年 第16卷 第6期   页码 984-990 doi: 10.1007/s11684-022-0930-5

摘要： Nonpharmaceutical interventions (NPIs) have been commonly deployed to prevent and control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide decline in influenza prevalence. However, the influenza risk in China warrants cautious assessment. We conducted a cross-sectional, sero-epidemiological study in Shandong Province, Northern China in mid-2021. Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains. A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic. The overall seroprevalence values against A/H1N1pdm09, A/H3N2, B/Victoria, and B/Yamagata were 17.8% (95% CI 16.2%–19.5%), 23.5% (95% CI 21.7%–25.4%), 7.6% (95% CI 6.6%–8.7%), and 15.0 (95% CI 13.5%–16.5%), respectively, in the study period. The overall vaccination rate was extremely low (2.6%). Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals (P < 0.001). Notably, the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic ( P < 0.01). Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.

关键词： influenza virus     seroprevalence     antibody     COVID-19     cross-sectional study    

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Occurrence and distribution of micro- and mesoplastics in the high-latitude nature reserve, northernChina

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1534-7

摘要：

• The first study on micro(meso)plastics (MMPs) in the Liaohe River Reserve is reported.

关键词： Microplastics     Mesoplastics     Water     Sediment     Characteristic     Risk Assessment    

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In quest of the origin of ancient northern city of China: An implication from the Book of Odes

DAI Fudong

《结构与土木工程前沿（英文）》 2007年 第1卷 第4期   页码 389-392 doi: 10.1007/s11709-007-0052-9

摘要： Sorting out some paragraphs in (collection of the earliest poetry in China), this paper makes analysis of the formation, construction process and technology of the ancient northern city of China. Relevan

关键词： analysis     construction     formation     collection     paragraphs    

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Projections of heat-related excess mortality in China due to climate change, population and aging

《环境科学与工程前沿（英文）》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1732-y

摘要：

● Four scenarios were used to project heat-related excess mortality in China.

关键词： Heat-related excess mortality     LMDI     Aging     YLL     VSLY    

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

《医学前沿（英文）》 2021年 第15卷 第6期   页码 903-912 doi: 10.1007/s11684-021-0871-4

摘要： A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

关键词： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Water resource conservation promotes synergy between economy and environment in China’s northern drylands

《环境科学与工程前沿（英文）》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1462-y

摘要：

•Considering evenness provides a more accurate assessment of sustainable development.

关键词： Water conservation     Environmental protection     Industry transformation     Evenness     Sustainable development     Dryland    

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Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey

null

《医学前沿（英文）》 2012年 第6卷 第3期   页码 322-328 doi: 10.1007/s11684-012-0204-8

摘要：

The aim of this study was to determine the prevalence of overweight and obese subjects in the Shanghai population of China and its association with undiagnosed hypertension, by taking age, gender and place of residence (urban or suburban) into account. A cross-sectional population-based survey was conducted in 2007. The sample included 13 359 participants aged 15–69 years. Weight, height, and blood pressure were recorded, and information about gender, age and place of residence was obtained. Overweight and obesity prevalence were calculated by the body mass index (BMI) definition recommended by Working Group on Obesity in China (normal weight, 18.5–23.9 kg/m2; overweight, 24–27.9 kg/m2; obesity,≥28 kg/m2). Undiagnosed hypertension was defined by China criteria in accord with that of WHO-ISH (subjects with systolic pressure≥140 mmHg, and/or diastolic pressure≥90 mmHg). Multiple logistic regression analyses were used to assess the association of overweight or obesity with undiagnosed hypertension by adjusting for age, gender and place of residence. The overall overweight, obesity, and undiagnosed hypertension prevalence were 27.6% (95% CI: 26.8–28.4), 6.6% (95% CI: 6.2–7.0), and 15.5% (95% CI: 14.9–16.1), respectively. Compared to normal weight subjects, the odds ratios (OR) for subjects who were overweight and had hypertension was 2.33 (95% CI: 2.10–2.59); that for obesity and hypertension was 4.27 (95% CI: 3.66–4.99). These data suggest that overweight and obesity prevalence and their association with undiagnosed hypertension are high in our study population.

关键词： overweight     obesity     undiagnosed hypertension     prevalence     association    

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natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease in Chinese Hanpopulation?

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 437-442 doi: 10.1007/s11684-009-0074-x

摘要： Natriuretic peptide precursor A (NPPA) is synthesized, stored, and released by atrial myocytes. Previous studies have shown that NPPA plays a significant role in the regulation of coronary circulation and in atherosclerosis. Rs5065 NPPA gene polymorphism leads to the translation of NPPA with two additional arginines and has been suggested to be associated with salt-sensitive hypertension. The purpose of the present study was to investigate the relationship between the rs5065 NPPA gene polymorphism and the risk of coronary heart disease (CHD) in Chinese Han population. We genotyped the single nucleotide polymorphism (SNP) rs5065 NPPA in the human NPPA gene in 1861 sex- and age-matched subjects, comprising of 904 CHD cases and 957 controls of Chinese Han population. Genotyping of SNP was performed with Taqman SNP allelic discrimination assays by means of an ABI 7900HT. Our study showed that the frequencies of rs5065 NPPA C allele in the case and the control groups were 0.012 and 0.005, respectively. There was significant difference in C allele frequency distribution between the two groups (OR=2.607, 95% CI: 1.197−5.678, =0.012). In the case group, there was significant difference between smokers and nonsmokers with subjects carrying C allele (=0.037), and no significant difference in gender, age, fasting total cholesterol (TC), triglycerides (TG), fasting plasma glucose (FPG), body mass index (BMI), and blood pressure (BP) between the cases and the controls (>0.05). Our results suggest that the C allele of rs5065 NPPA gene polymorphism may be associated with the risk of CHD.

关键词： natriuretic peptide precursor A     coronary heart disease     gene polymorphism     allelic discrimination     polymorphism     single nucleotide    

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北方旱区农田水肥效应分析

高亚军,李生秀

《中国工程科学》 2002年 第4卷 第7期   页码 74-79

摘要：

结合多年的田间试验研究，对前人诸多研究结果进行了总结和深入分析。结果表明：农田水肥效应大小与试验方法有关，田间试验与模拟试验得到的结论相反。主要原因在于研究中"水"的概念各不相同，从旱棚试验或盆栽试验的结果推断水肥效应与实际情况相距较大。多数情况下，养分亏缺仍是北方旱区作物增产的主要限制因子。灌水的效果取决于土壤底墒、生育期降水、土壤肥力及灌水时期等各种因素。在现有的水资源条件下，提高养分供应水平是北方旱区大部分农田作物增产的主要途径。加强夏闲期降水的蓄积、提高土壤底墒是冬麦区作物高产的重要条件。

关键词： 水肥效应     北方旱区     田间试验     模拟试验    

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Genetic diversity and population structure of indigenous chicken breeds in South China

Xunhe HUANG,Jinfeng ZHANG,Danlin HE,Xiquan ZHANG,Fusheng ZHONG,Weina LI,Qingmei ZHENG,Jiebo CHEN,Bingwang DU

《农业科学与工程前沿（英文）》 2016年 第3卷 第2期   页码 97-101 doi: 10.15302/J-FASE-2016102

摘要： A total of 587 individuals from 12 indigenous chicken breeds from South China and two commercial breeds were genotyped for 26 microsatellites to investigate the genetic diversity and population structure. All microsatellites were found to be polymorphic. The number of alleles per locus ranged from 5 to 36, with an average of 12.10 ± 7.00 (SE). All breeds, except White Recessive Rock, had high allelic polymorphism (>0.5). Higher genetic diversity was revealed in the indigenous chicken breeds rather than in the commercial breeds. Potential introgression from the commercial breeds into the indigenous chickens was also detected. The population structure of these indigenous chicken breeds could be explained by their geographical distribution, which suggested the presence of independent history of breed formation. Data generated in this study will provide valuable information to the conservation for indigenous chicken breeds in future.

关键词： microsatellites     genetic diversity     population structure     indigenous chicken     South China     conservation    

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Simulation of bubble column reactors using CFD coupled with a population balance model

Tiefeng WANG

《化学科学与工程前沿（英文）》 2011年 第5卷 第2期   页码 162-172 doi: 10.1007/s11705-009-0267-5

摘要： Bubble columns are widely used in chemical and biochemical processes due to their excellent mass and heat transfer characteristics and simple construction. However, their fundamental hydrodynamic behaviors, which are essential for reactor scale-up and design, are still not fully understood. To develop design tools for engineering purposes, much research has been carried out in the area of computational fluid dynamics (CFD) modeling and simulation of gas-liquid flows. Due to the importance of the bubble behavior, the bubble size distribution must be considered in the CFD models. The population balance model (PBM) is an effective approach to predict the bubble size distribution, and great efforts have been made in recent years to couple the PBM into CFD simulations. This article gives a selective review of the modeling and simulation of bubble column reactors using CFD coupled with PBM. Bubble breakup and coalescence models due to different mechanisms are discussed. It is shown that the CFD-PBM coupled model with proper bubble breakup and coalescence models and interphase force formulations has the ability of predicting the complex hydrodynamics in different flow regimes and, thus, provides a unified description of both the homogeneous and heterogeneous regimes. Further study is needed to improve the models of bubble coalescence and breakup, turbulence modification in high gas holdup, and interphase forces of bubble swarms.

关键词： bubble column     computational fluid dynamics     bubble breakup and coalescence     population balance model     bubble size distribution    

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Effects of hydraulic retention time on nitrification activities and population dynamics of a conventional

Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA

《环境科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 43-48 doi: 10.1007/s11783-012-0397-8

摘要： The effects of hydraulic retention time (HRT) on the nitrification activities and population dynamics of a conventional activated sludge system fed with synthetic inorganic wastewater were investigated over a period of 260 days. When the HRT was gradually decreased from 30 to 5 h, the specific ammonium-oxidizing rates (SAOR) varied between 0.32 and 0.45 kg (kg mixed liquor suspended solids (MLSS)·d) , and the specific nitrate-forming rates (SNFR) increased from 0.11 to 0.50 kg (kg MLSS·d) , showing that the decrease in HRT led to a significant increase in the nitrite oxidation activity. According to fluorescence in situ hybridization (FISH) analysis results, the proportion of ammonia-oxidizing bacteria (AOBs) among the total bacteria decreased from 33% to 15% with the decrease in HRT, whereas the fraction of nitrite-oxidizing bacteria (NOBs), particularly the fast-growing sp., increased significantly (from 4% to 15% for NOBs and from 1.5% to 10.6% for sp.) with the decrease in HRT, which was in accordance with the changes in SNFR. A short HRT favored the relative growth of NOBs, particularly the fast-growing sp., in the conventional activated sludge system.

关键词： ammonia-oxidizing bacteria     hydraulic retention time     nitrification activity     nitrite-oxidizing bacteria     population dynamics    

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标题 作者 时间 类型 操作

Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of NorthernChina?

null

期刊论文

南海北部深水区油气勘探进展与未来展望

米立军 ,周守为 ,谢玉洪 ,张功成 ,杨海长

期刊论文

Improving simulations of sulfate aerosols during winter haze over Northern China: the impacts of heterogeneous

Meng Gao,Gregory R. Carmichael,Yuesi Wang,Dongsheng Ji,Zirui Liu,Zifa Wang

期刊论文

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

期刊论文

Occurrence and distribution of micro- and mesoplastics in the high-latitude nature reserve, northernChina

期刊论文

In quest of the origin of ancient northern city of China: An implication from the Book of Odes

DAI Fudong

期刊论文

Projections of heat-related excess mortality in China due to climate change, population and aging

期刊论文

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

期刊论文

Water resource conservation promotes synergy between economy and environment in China’s northern drylands

期刊论文

Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey

null

期刊论文

natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease in Chinese Hanpopulation?

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

期刊论文

北方旱区农田水肥效应分析

高亚军,李生秀

期刊论文

Genetic diversity and population structure of indigenous chicken breeds in South China

Xunhe HUANG,Jinfeng ZHANG,Danlin HE,Xiquan ZHANG,Fusheng ZHONG,Weina LI,Qingmei ZHENG,Jiebo CHEN,Bingwang DU

期刊论文

Simulation of bubble column reactors using CFD coupled with a population balance model

Tiefeng WANG

期刊论文

Effects of hydraulic retention time on nitrification activities and population dynamics of a conventional

Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA

期刊论文